2019 women’s health update- new meds to control pain and prevent disease

In a previous post I gave you updates about hormones, the heart, and HPV. Here is the link-

Women’s health update, part 1

In this post I’ll review some new drugs that treat conditions exclusive to or common in women.

I’m illustrating this post with covers of books written by women; I have reviewed all of these books on my blog, so I’ll include those links also. Please note these are affiliate links, so if you do happen to use them for a purchase you will help me fund this blog.

Photo by rawpixel.com on Pexels.com

Relieving the pain of endometriosis

Women with endometriosis suffer infertility, excessive bleeding, painful periods and pelvic pain unrelated to periods. In endometriosis, uterine tissue grows outside the uterus. It can be difficult to diagnose, requiring invasive procedures to discover. Treatment depends on the goal, whether pregnancy, pain relief, or both. Short of surgery, hormonal therapy has been the mainstay of treatment.

A new hormonal drug released last year, elagolix, brand name Orilissa, is the first of its kind specifically developed and approved to treat “moderate to severe” endometriosis pain. It does not help with infertility. AbbVie, the pharmaceutical company which developed the drug, has priced it at $844 per month, or about $10000 per year, retail.( per Reuters report) Patients may pay less depending on insurance.

 

Stop bleeding fibroids

Researchers are studying elagolix and another hormonal drug ulipristal for treating uterine fibroids. Fibroids are growths within the uterine that can cause pain and excessive bleeding. Initial trials show both of these drugs can significantly decrease bleeding and pain. However, neither is currently FDA approved for treating fibroid.

Easing dyspareunia

After menopause many women develop atrophy of the vagina, making it thin, dry, and easily irritated, leading to painful sex, or dyspareunia. A new intravaginal medication, prasterone,brand name Intrarosa, can help relieve the discomfort. Studies show it may also help improve sexual desire and arousal, but it is not labeled for this.

Manufactured by AMAG Pharmaceuticals, it is for “moderate to severe” symptoms. Also known as DHEA, it is a steroid that transforms into estrogen in the vagina ,administered as a once daily vaginal insert at bedtime, applied with an applicator. According to goodrx.com,a 30 day supply costs about $213.

DHEA can be purchased as an over-the-counter, non-regulated product, whose effectiveness and safety are unknown. A one-month supply of 50 mg tablets may cost $5.

Other options for treating vaginal atrophy symptoms are oral or vaginal estrogen and/or vaginal lubricants.

Support Independent Bookstores - Visit IndieBound.org Support Independent Bookstores - Visit IndieBound.org

Prevention of migraine pain and disability

Migraine, although not exclusive to women,occurs much more frequently in them than men. For infrequent headaches,non opiate pain relievers are effective and recommended. But for severe, frequent, or persistent symptoms prevention is recommended to improve quality of life. Several oral meds are effective but two new injectable drugs show promise.

Botox, onabotulinumtoxin A, has been FDA approved for treating chronic migraine, meaning patients with frequent headaches and other migraine symptoms for at least 3 months.

Yes the same drug used to treat wrinkles,Botox, can prevent migraine

Manufactured by Allergan, a vial containing 200 units costs $1452, per goodrx.com. For migraine, the drug is injected in the upper facial muscles by a physician specifically trained in its use.

Another novel therapy uses the immune system to fight migraine. Monoclonal antibodies bind to a calcitonin gene-related peptide receptor which is responsible for transmitting migraine pain. The antibodies are produced in a laboratory but work like antibodies naturally produced by the body. They are being used to treat cancers and some forms of arthritis.

Three of these drugs are available

  • Erenumab-brand
  • Fremanezumab-Ajoovy
  • Galcanezumab-Emgality

 

They are administered as subcutaneous injections (under the skin) monthly. According to a Medscape, average cost is $600 per month.

You may want to review my previous post about non-drug ways to manage migraine.

Simple and effective ways to manage chronic pain

Preventing cervical cancer with the HPV vaccine

I mentioned this in my previous post about women’s health but it fits here also.

Infection with the HPV, human papillomavirus, causes genital warts and changes in the cervix called CIN which can lead to cervical cancer.

According to a review of clinical trials by Cochran, vaccination against this virus effectively prevents infection and thus fewer cases of CIN. Since a significant percentage of CIN progresses to cancer, we can expect fewer women will develop invasive cervical cancer, the 4th most common cancer in women worldwide.

The vaccine, Gardasail 9, originally approved for use in females ages 9 to 26 years,received FDA approval for use up to age 45 years.

Stopping shingles with the zoster vaccine

And speaking of vaccines, a new zoster (shingles) vaccine, Shingrix, prevents the painful rash much more effectively than the original vaccine Zostavax. It ranges in effectiveness from 91% to 97% at preventing shingles, depending on age. The first vaccine was 51% effective.

Zoster is a reactivation of the varicella virus that causes chickenpox. It causes a painful rash known as shingles;the pain may continue after the rash is gone. It can happen at any age, but symptoms tend to be worst in older persons.

exploring the HEART of health through books

Thanks for joining me to review new steps in women’s health and review some fine women authors. I hope you will follow the links to my reviews and read some or all of these books. When you do, I would love to know your reaction. I might use your comments in an update.

I appreciate all of you who follow this blog; there are numerous other blogs to choose from so I am honored you chose to spend some time here. A special welcome to all my new followers from this past month.

Until next time,

                              Dr. Aletha 

This blog may earn a commission if you use these affiliate links from Barnes & Noble , AvaCare Medical, and Aaptiv.
40% Off Select Collectibles
Advertisements

Simple and effective ways to manage chronic pain -part 2 of a series

In a previous post I talked about non-drug methods to manage pain in the spine-neck and back. You may want to review it now, but reading  this one first is fine. This post will focus on other painful conditions.

While people often discover methods to relieve pain that work for them, I am focusing here on treatments that are supported in the medical literature or recommended by knowledgeable professionals. For this post, I reviewed many articles which summarized current studies.

Finding trustworthy medical information

How do doctors know what works and what doesn’t? Since medical knowledge has changed since we went to medical school , how do we know what is current information?

We read literature pertinent to our fields on a regular basis, attend conferences, and talk to other doctors. But when we need a specific question answered , we do what you do-we Google it.

shelves in a library with adjacent computers

the Centers for Disease Control and Prevention (CDC) Library, located on the organization’s campus, in Atlanta, Georgia. The CDC collections span the field of public health. Print and electronic resources cover such topics as disease prevention, epidemiology, infectious diseases, global health, chronic diseases, environmental health, injury prevention, and occupational safety and health. The main library in Atlanta and selected branch libraries are open to the public. used courtesy CDC/ Emily Weyant; MSLIS; ORISE Fellow

One of the most frequently reviewed is PubMed listing  more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. The service is free and anyone can use it. PubMed is a service of  the National Library of Medicine, the largest biomedical library in the world ,located in Bethesda, Maryland,

Another major reference is the Cochrane Library, a collection of databases in medicine and other healthcare specialties ; a fee is charged to use this service.

Basic points about complementary treatments for pain management

We should use medication and surgery when appropriate, but when these can’t be used or are not helpful, we can consider alternative methods, or what I and other doctors prefer to call complementary or integrative treatment.

This post focuses on symptom relief, not necessarily curative treatment.

Herbals and supplements are drugs and can be effective for certain conditions, but this post will discuss non-drug treatments only.

Many cases of pain improve spontaneously with no specific treatment.

Almost everything works sometimes.

There are few if any down side to any of these treatments. Used under supervision they are unlikely to have adverse side effects or result in long term complications.

The most important ingredient in managing a chronic or persistent condition is having a therapeutic relationship with your physician and other healthcare professionals- physical therapist , mental health counselor, nutritionist.

SIMPLE AND EFFECTIVE WAYS TO MANAGE CHRONIC PAIN-WATERCRESSWORDS.COM

Migraine

Migraine is more than just a bad headache; it is a disorder of the brain which causes pain as well as other common symptoms including nausea, vomiting, and sensitivity to light and noise.  Dizziness, numbness, and  loss of vision occur less frequently.

diagram of the human brain.

The major parts of the brain, including the pineal gland, cerebellum, spinal cord, brain stem, pituitary gland, and cerebrum are labeled. I photo courtesy of Source: National Cancer Institute Creator: Alan Hoofring (Illustrator)

Most people with migraine require some type of medication for relief, but non-drug treatments can supplement meds and can be helpful for prevention. Integrative treatments that work according to studies include

  • acupuncture
  • biofeedback
  • CBT-cognitive behavioral therapy
  • exercise
  • meditation
  • relaxation training
  • yoga

Fibromyalgia

I mentioned fibromyalgia in my post about back and neck pain, but  include it here  since it causes pain in other body areas.

Fibromyalgia seems to be a disorder of nerves which makes them super sensitive, leading to diffuse muscle and joint pain that can become disabling. Complementary treatments recommended include

  • Mind-body-guided imagery, hypnosis, biofeedback, mindfulness meditation , relaxation
  • Tai chi
  • Hydrotherapy, balneotherapy

Osteoarthritis of the knees (degenerative arthritis)

It is likely that arthritis in other joints responds to these therapies but there aren’t enough large studies to confirm.

  • Acupuncture,
  • tai chi
  • walking and  strengthening exercises
  • Balneotherapy-bathing in hot water mineral baths

people in a gym exercising

photo courtesy Amanda Mills, CDC.gov, Public Health Image Library

 

 

 

 

Tessa Frank  discusses how she became frustrated when increasing doses of opioids didn’t relieve her chronic pain, and what she’s doing now to manage her pain.

How I’m Managing My Chronic Pain Without Opioids

“While I no longer use opioids, I do use non-opioid prescription medications and a spinal cord stimulator to provide pain relief for my CRPS, complex regional pain syndrome, a chronic, debilitating neuropathic pain condition.

I’m also hyperaware of how stress triggers my increased feelings of pain, so to mitigate stress, I personally have found relief in meditation, relaxation and yoga among other approaches.” (excerpt)

 

 

 

 

If you didn’t read it earlier, here’s a link to the previous post about treating pain, along with a brief excerpt.

Surprising effective ways to relieve back pain

“Pain in the spine results from many medical conditions, ranging from minor to life threatening. Most cases are due to routine or excessive physical activity or a minor injury causing strain of the muscles, tendons, and ligaments, and will go away with no or minimal intervention in less than 12 weeks.”

 

 

The affiliate product links in this post are for illustration and information only, and do not imply endorsement.

I am grateful when you like and share this post on social media.

Please consider helping support this blog by using my affiliates. You’ll find links in the side bars, on the home page, and on the resource page.

In a future post I will talk about  non-drug treatments for other conditions.

always exploring the HEART of health with you.

                       Dr. Aletha  WATERCRESSWORDS.COM-exploring the HEART of health